Understanding function and specificity of de-ubiquitylating enzymes (DUBs) is a major goal of current research, since DUBs are key regulators of ubiquitylation events and have been shown to be mutated in human diseases.Most DUBs are cysteine proteases, relying on a catalytic triad of cysteine, histidine and aspartate to cleave the isopeptide bond b
Chronic urticaria (CU) is one of the most common skin disorders worldwide.Among the inducible subgroup of CU, cold urticaria (ColdU) can affect both children and adults and is the only type associated with the risk of anaphylaxis without cofactors.In 30x24x24 wall cabinet the scientific literature, data about cold anaphylaxis (ColdA) are poor, espe
Characterising the structure of cellular metals is g5210t-p90 a difficult task.The internal structure of cellular metals can be determined using micro-computed tomography (mCT).However, mCT scanning provides digital images in greyscale with various problematic artefacts.In addition, the grey intensity of cellular metals usually varies greatly due t